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KMID : 0043320060290110937
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Archives of Pharmacal Research
2006 Volume.29 No. 11 p.937 ~ p.941
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Cytotoxic and ACAT-inhibitory Sesquiterpene Lactones from the Root of Ixeris dentata forma albiflora
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Ahn Eun-Mi
Park Mi-Hyun
Kim Wha-Young
Kwon Byoung-Mog
Baek Nam-In
Bang Myun-Ho
Song Myoung-Chong
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Abstract
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Ixeris dentata forma albiflora was extracted with 80% aqueous MeOH, and the concentrated extract was partitioned with EtOAc, n-BuOH and . Eight sesquiterpenes were isolated through repeated silica gel and octadecyl silica gel () column chromatography of the EtOAc and n-BuOH fractions. Physicochemical analysis using NMR, MS and IR revealed the chemical structures of the sesquiterpenes, which were zaluzanin (1), 9a-hydroxyguaian-4(15), 10(14), 11 (13)-triene-6, 12-olide(2), -4(15), 10(14)-diene-6, 12-olide (3), -10(14)-ene-6, 12-olide (4), ixerin M (5), glucozaluzanin C (6), crepiside I (7), and ixerin D (8). This is the first time that these sesquiterpene lactones have been isolated from this plant. Compounds 1, 2 and 7 revealed relatively high cytotoxicities on human colon carcinoma cell and lung adeno-carcinoma cell, while compounds 5 and 7 showed acyl-CoA: cholesterol acyltransferase (ACAT) inhibitory activity.
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KEYWORD
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Ixeris dentata forma albiflora, Sesquiterpene lactone, ACAT, HT29, A549
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